| Player | Pos | Team | GP | G | A | Pts | +/- | PIM | PPG | SHG | GWG | TOI | S | PtsPG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jack Eichel | C | Buf | 32 | 20 | 24 | 44 | 13 | 16 | 5 | 0 | 4 | 21:37 | 113 | 1.38 |
| Victor Olofsson | LW | Buf | 32 | 12 | 16 | 28 | 4 | 4 | 7 | 0 | 1 | 18:15 | 79 | 0.88 |
| Sam Reinhart | RW | Buf | 32 | 12 | 13 | 25 | -2 | 14 | 1 | 0 | 0 | 20:19 | 59 | 0.78 |
| Jeff Skinner | LW | Buf | 32 | 11 | 7 | 18 | -3 | 14 | 0 | 0 | 1 | 17:26 | 118 | 0.56 |
| Rasmus Dahlin | D | Buf | 24 | 1 | 15 | 16 | 2 | 20 | 0 | 0 | 0 | 18:59 | 33 | 0.67 |
| Rasmus Ristolainen | D | Buf | 32 | 2 | 12 | 14 | 9 | 26 | 1 | 0 | 0 | 23:08 | 67 | 0.44 |
| Marcus Johansson | C | Buf | 25 | 5 | 8 | 13 | 0 | 12 | 1 | 0 | 1 | 17:12 | 23 | 0.52 |
| Johan Larsson | C | Buf | 29 | 4 | 8 | 12 | 8 | 16 | 0 | 0 | 0 | 14:38 | 32 | 0.41 |
| Brandon Montour | D | Buf | 18 | 2 | 7 | 9 | 5 | 10 | 0 | 0 | 0 | 18:17 | 41 | 0.50 |
| Jimmy Vesey | RW | Buf | 29 | 3 | 6 | 9 | 10 | 9 | 0 | 1 | 1 | 13:28 | 46 | 0.31 |
| Conor Sheary | RW | Buf | 27 | 5 | 4 | 9 | 4 | 4 | 1 | 0 | 1 | 13:19 | 44 | 0.33 |
| Henri Jokiharju | D | Buf | 32 | 3 | 6 | 9 | 5 | 22 | 1 | 0 | 0 | 16:39 | 41 | 0.28 |
| Zemgus Girgensons | C | Buf | 32 | 5 | 4 | 9 | 3 | 8 | 0 | 0 | 1 | 12:47 | 35 | 0.28 |
| Casey Mittelstadt | W | Buf | 31 | 4 | 5 | 9 | -5 | 2 | 1 | 0 | 1 | 12:46 | 34 | 0.29 |
| Kyle Okposo | RW | Buf | 22 | 3 | 4 | 7 | 1 | 20 | 0 | 0 | 1 | 10:47 | 25 | 0.32 |
| Jake McCabe | D | Buf | 30 | 2 | 5 | 7 | -3 | 16 | 0 | 0 | 1 | 20:02 | 38 | 0.23 |
| Marco Scandella | D | Buf | 24 | 2 | 5 | 7 | 13 | 4 | 0 | 0 | 0 | 16:35 | 31 | 0.29 |
| Colin Miller | D | Buf | 25 | 1 | 4 | 5 | -4 | 8 | 0 | 0 | 1 | 17:52 | 38 | 0.20 |
| Zach Bogosian | D | Buf | 10 | 0 | 3 | 3 | 2 | 4 | 0 | 0 | 0 | 18:45 | 9 | 0.30 |
| Rasmus Asplund | C | Buf | 14 | 1 | 2 | 3 | 4 | 4 | 0 | 0 | 0 | 11:32 | 23 | 0.21 |
| Vladimir Sobotka | C | Buf | 16 | 1 | 2 | 3 | 2 | 4 | 0 | 0 | 0 | 14:16 | 23 | 0.19 |
| Evan Rodrigues | C | Buf | 16 | 0 | 2 | 2 | -3 | 0 | 0 | 0 | 0 | 11:33 | 26 | 0.13 |
| Curtis Lazar | C | Buf | 6 | 1 | 0 | 1 | -2 | 7 | 0 | 0 | 0 | 8:51 | 2 | 0.17 |
| John Gilmour | LW | Buf | 4 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 17:03 | 5 | 0.00 |
| Linus Ullmark | G | Buf | 17 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 59:56 | 0 | 0.00 |
| Jean-Sebastien Dea | C | Buf | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5:53 | 0 | 0.00 |
| Tage Thompson | RW | Buf | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6:59 | 0 | 0.00 |
| Carter Hutton | G | Buf | 15 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 60:24 | 0 | 0.00 |
