| Player | Pos | Team | GP | G | A | Pts | +/- | PIM | PPG | SHG | GWG | TOI | S | PtsPG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jack Eichel | C | Buf | 55 | 18 | 44 | 62 | 0 | 18 | 4 | 0 | 2 | 20:04 | 215 | 1.13 |
| Jeff Skinner | LW | Buf | 58 | 36 | 17 | 53 | 6 | 24 | 8 | 0 | 7 | 18:42 | 189 | 0.91 |
| Sam Reinhart | RW | Buf | 58 | 14 | 37 | 51 | 2 | 12 | 1 | 0 | 0 | 18:42 | 126 | 0.88 |
| Rasmus Ristolainen | D | Buf | 58 | 5 | 31 | 36 | -21 | 24 | 1 | 0 | 2 | 25:00 | 145 | 0.62 |
| Rasmus Dahlin | D | Buf | 58 | 6 | 26 | 32 | 3 | 20 | 3 | 0 | 2 | 20:49 | 115 | 0.55 |
| Jason Pominville | RW | Buf | 52 | 13 | 11 | 24 | 5 | 4 | 1 | 0 | 3 | 12:42 | 96 | 0.46 |
| Conor Sheary | LW | Buf | 54 | 9 | 15 | 24 | -1 | 12 | 3 | 0 | 2 | 14:38 | 96 | 0.44 |
| Kyle Okposo | RW | Buf | 57 | 10 | 12 | 22 | -11 | 37 | 5 | 0 | 2 | 13:53 | 112 | 0.39 |
| Evan Rodrigues | W | Buf | 52 | 8 | 13 | 21 | -6 | 18 | 2 | 0 | 1 | 15:19 | 120 | 0.40 |
| Casey Mittelstadt | C | Buf | 56 | 8 | 11 | 19 | -6 | 8 | 2 | 0 | 1 | 13:28 | 82 | 0.34 |
| Zach Bogosian | D | Buf | 51 | 2 | 12 | 14 | -4 | 42 | 0 | 0 | 0 | 21:37 | 70 | 0.27 |
| Jake McCabe | D | Buf | 48 | 4 | 10 | 14 | -4 | 33 | 0 | 1 | 0 | 18:47 | 52 | 0.29 |
| Zemgus Girgensons | C | Buf | 51 | 3 | 9 | 12 | -6 | 9 | 0 | 0 | 0 | 13:37 | 53 | 0.24 |
| Tage Thompson | RW | Buf | 50 | 7 | 4 | 11 | -13 | 18 | 1 | 0 | 0 | 12:28 | 89 | 0.22 |
| Vladimir Sobotka | LW | Buf | 55 | 3 | 7 | 10 | -15 | 16 | 0 | 0 | 0 | 14:37 | 62 | 0.18 |
| Marco Scandella | D | Buf | 48 | 4 | 6 | 10 | -5 | 20 | 0 | 0 | 1 | 18:11 | 71 | 0.21 |
| Johan Larsson | LW | Buf | 50 | 5 | 4 | 9 | -4 | 25 | 0 | 1 | 0 | 14:34 | 59 | 0.18 |
| Nathan Beaulieu | D | Buf | 27 | 3 | 4 | 7 | 0 | 30 | 0 | 0 | 0 | 14:46 | 32 | 0.26 |
| Lawrence Pilut | D | Buf | 24 | 1 | 5 | 6 | -2 | 18 | 0 | 0 | 0 | 17:18 | 25 | 0.25 |
| Casey Nelson | D | Buf | 22 | 1 | 4 | 5 | 6 | 4 | 0 | 0 | 0 | 14:42 | 17 | 0.23 |
| Patrik Berglund | C | Buf | 23 | 2 | 2 | 4 | -5 | 6 | 0 | 0 | 0 | 13:03 | 25 | 0.17 |
| C.J. Smith | LW | Buf | 9 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 11:26 | 16 | 0.22 |
| Linus Ullmark | G | Buf | 26 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 57:18 | 0 | 0.04 |
| Remi Elie | RW | Buf | 16 | 0 | 1 | 1 | -3 | 2 | 0 | 0 | 0 | 10:21 | 9 | 0.06 |
| Matt Tennyson | D | Buf | 4 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 10:45 | 4 | 0.00 |
| Carter Hutton | G | Buf | 35 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 57:18 | 0 | 0.00 |
| Brendan Guhle | D | Buf | 2 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 11:41 | 1 | 0.00 |
| Matt Hunwick | D | Buf | 6 | 0 | 0 | 0 | -3 | 0 | 0 | 0 | 0 | 16:00 | 4 | 0.00 |
