| Player | Pos | Team | GP | G | A | Pts | +/- | PIM | PPG | SHG | GWG | TOI | S | PtsPG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jack Eichel | C | Buf | 77 | 28 | 54 | 82 | -11 | 26 | 8 | 0 | 2 | 20:26 | 303 | 1.06 |
| Sam Reinhart | RW | Buf | 82 | 22 | 43 | 65 | -10 | 16 | 2 | 0 | 1 | 18:57 | 180 | 0.79 |
| Jeff Skinner | LW | Buf | 82 | 40 | 23 | 63 | 0 | 36 | 8 | 0 | 7 | 18:31 | 268 | 0.77 |
| Rasmus Dahlin | D | Buf | 82 | 9 | 35 | 44 | -13 | 34 | 5 | 0 | 4 | 21:09 | 177 | 0.54 |
| Rasmus Ristolainen | D | Buf | 78 | 5 | 38 | 43 | -41 | 38 | 1 | 0 | 2 | 24:38 | 182 | 0.55 |
| Brandon Montour | D | Buf | 82 | 8 | 27 | 35 | -20 | 56 | 1 | 0 | 2 | 22:27 | 181 | 0.43 |
| Conor Sheary | LW | Buf | 78 | 14 | 20 | 34 | -18 | 12 | 4 | 0 | 3 | 14:37 | 147 | 0.44 |
| Jason Pominville | RW | Buf | 73 | 16 | 15 | 31 | -4 | 4 | 1 | 0 | 3 | 12:28 | 134 | 0.42 |
| Evan Rodrigues | W | Buf | 74 | 9 | 20 | 29 | -7 | 25 | 2 | 0 | 1 | 15:50 | 168 | 0.39 |
| Kyle Okposo | RW | Buf | 78 | 14 | 15 | 29 | -9 | 41 | 7 | 0 | 2 | 13:47 | 147 | 0.37 |
| Casey Mittelstadt | C | Buf | 77 | 12 | 13 | 25 | -19 | 10 | 3 | 0 | 1 | 13:27 | 118 | 0.32 |
| Zach Bogosian | D | Buf | 65 | 3 | 16 | 19 | -5 | 52 | 0 | 1 | 0 | 21:38 | 93 | 0.29 |
| Zemgus Girgensons | W | Buf | 72 | 5 | 13 | 18 | -11 | 17 | 0 | 0 | 0 | 13:37 | 78 | 0.25 |
| Johan Larsson | C | Buf | 73 | 6 | 8 | 14 | -8 | 37 | 0 | 1 | 0 | 14:18 | 79 | 0.19 |
| Jake McCabe | D | Buf | 59 | 4 | 10 | 14 | -4 | 35 | 0 | 1 | 0 | 18:57 | 64 | 0.24 |
| Vladimir Sobotka | C | Buf | 69 | 5 | 8 | 13 | -20 | 26 | 0 | 0 | 0 | 14:11 | 71 | 0.19 |
| Marco Scandella | D | Buf | 63 | 6 | 7 | 13 | -13 | 26 | 0 | 0 | 1 | 17:37 | 83 | 0.21 |
| Tage Thompson | LW | Buf | 65 | 7 | 5 | 12 | -22 | 20 | 1 | 0 | 0 | 12:08 | 108 | 0.18 |
| Casey Nelson | D | Buf | 38 | 1 | 5 | 6 | 1 | 13 | 0 | 0 | 0 | 15:25 | 37 | 0.16 |
| Lawrence Pilut | D | Buf | 33 | 1 | 5 | 6 | -8 | 20 | 0 | 0 | 0 | 17:25 | 37 | 0.18 |
| Victor Olofsson | RW | Buf | 6 | 2 | 2 | 4 | 1 | 2 | 2 | 0 | 0 | 18:01 | 21 | 0.67 |
| Patrik Berglund | C | Buf | 23 | 2 | 2 | 4 | -5 | 6 | 0 | 0 | 0 | 13:03 | 25 | 0.17 |
| Alexander Nylander | LW | Buf | 12 | 2 | 2 | 4 | -4 | 4 | 1 | 0 | 0 | 12:12 | 16 | 0.33 |
| Scott Wilson | LW | Buf | 15 | 0 | 3 | 3 | -8 | 4 | 0 | 0 | 0 | 11:27 | 25 | 0.20 |
| C.J. Smith | LW | Buf | 11 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 10:39 | 18 | 0.18 |
| Matt Hunwick | D | Buf | 14 | 0 | 2 | 2 | -7 | 4 | 0 | 0 | 0 | 15:41 | 10 | 0.14 |
| Carter Hutton | G | Buf | 50 | 0 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 56:48 | 0 | 0.02 |
| Linus Ullmark | G | Buf | 37 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 56:49 | 0 | 0.03 |
| Remi Elie | LW | Buf | 16 | 0 | 1 | 1 | -3 | 2 | 0 | 0 | 0 | 10:21 | 9 | 0.06 |
| Matt Tennyson | D | Buf | 4 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 10:45 | 4 | 0.00 |
| Daniel O'Regan | C | Buf | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11:56 | 2 | 0.00 |
| William Borgen | D | Buf | 4 | 0 | 0 | 0 | -5 | 0 | 0 | 0 | 0 | 16:33 | 2 | 0.00 |
