| Player | Pos | Team | GP | G | A | Pts | +/- | PIM | PPG | SHG | GWG | TOI | S | PtsPG |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jack Eichel | C | Buf | 48 | 28 | 34 | 62 | 13 | 30 | 6 | 1 | 6 | 21:57 | 163 | 1.29 |
| Sam Reinhart | RW | Buf | 49 | 17 | 24 | 41 | -3 | 20 | 4 | 0 | 1 | 20:28 | 99 | 0.84 |
| Victor Olofsson | LW | Buf | 42 | 16 | 19 | 35 | -1 | 4 | 9 | 0 | 3 | 18:48 | 99 | 0.83 |
| Rasmus Dahlin | D | Buf | 41 | 3 | 25 | 28 | -1 | 30 | 1 | 0 | 1 | 19:03 | 67 | 0.68 |
| Rasmus Ristolainen | D | Buf | 49 | 5 | 18 | 23 | 2 | 36 | 2 | 0 | 0 | 22:47 | 95 | 0.47 |
| Marcus Johansson | LW | Buf | 42 | 6 | 15 | 21 | -7 | 20 | 1 | 0 | 1 | 17:41 | 56 | 0.50 |
| Jeff Skinner | LW | Buf | 39 | 11 | 8 | 19 | -9 | 14 | 0 | 0 | 1 | 16:58 | 128 | 0.49 |
| Conor Sheary | LW | Buf | 42 | 7 | 9 | 16 | 0 | 6 | 1 | 0 | 1 | 13:13 | 68 | 0.38 |
| Jimmy Vesey | LW | Buf | 45 | 6 | 8 | 14 | 12 | 13 | 0 | 1 | 1 | 13:38 | 67 | 0.31 |
| Henri Jokiharju | D | Buf | 49 | 4 | 9 | 13 | 0 | 28 | 1 | 0 | 0 | 16:49 | 58 | 0.27 |
| Zemgus Girgensons | W | Buf | 49 | 9 | 4 | 13 | 0 | 10 | 0 | 1 | 1 | 13:40 | 59 | 0.27 |
| Kyle Okposo | RW | Buf | 38 | 5 | 7 | 12 | -3 | 26 | 1 | 0 | 1 | 12:27 | 51 | 0.32 |
| Johan Larsson | C | Buf | 43 | 4 | 8 | 12 | 5 | 20 | 0 | 0 | 0 | 14:58 | 41 | 0.28 |
| Brandon Montour | D | Buf | 35 | 3 | 9 | 12 | 5 | 20 | 0 | 0 | 0 | 18:20 | 62 | 0.34 |
| Michael Frolik | RW | Buf | 44 | 6 | 6 | 12 | -10 | 24 | 0 | 2 | 1 | 12:21 | 60 | 0.27 |
| Casey Mittelstadt | C | Buf | 31 | 4 | 5 | 9 | -5 | 2 | 1 | 0 | 1 | 12:46 | 34 | 0.29 |
| Curtis Lazar | C | Buf | 19 | 4 | 4 | 8 | 1 | 7 | 0 | 0 | 0 | 11:18 | 13 | 0.42 |
| Jake McCabe | D | Buf | 46 | 2 | 6 | 8 | -3 | 33 | 0 | 0 | 1 | 18:55 | 49 | 0.17 |
| Colin Miller | D | Buf | 33 | 1 | 6 | 7 | -4 | 18 | 0 | 0 | 1 | 17:03 | 49 | 0.21 |
| Evan Rodrigues | C | Buf | 28 | 2 | 3 | 5 | -6 | 8 | 1 | 0 | 1 | 10:52 | 49 | 0.18 |
| Zach Bogosian | D | Buf | 18 | 1 | 4 | 5 | 3 | 10 | 0 | 0 | 0 | 16:49 | 16 | 0.28 |
| Rasmus Asplund | C | Buf | 28 | 1 | 2 | 3 | -4 | 6 | 0 | 0 | 0 | 10:53 | 34 | 0.11 |
| Vladimir Sobotka | W | Buf | 16 | 1 | 2 | 3 | 2 | 4 | 0 | 0 | 0 | 14:16 | 23 | 0.19 |
| John Gilmour | LW | Buf | 4 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 17:03 | 5 | 0.00 |
| Scott Wilson | LW | Buf | 2 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 0 | 12:20 | 3 | 0.00 |
| Jean-Sebastien Dea | C | Buf | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5:53 | 0 | 0.00 |
| Dalton Smith | LW | Buf | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 1:26 | 0 | 0.00 |
| Linus Ullmark | G | Buf | 32 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 59:43 | 0 | 0.00 |
| Tage Thompson | LW | Buf | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6:59 | 0 | 0.00 |
| Lawrence Pilut | D | Buf | 6 | 0 | 0 | 0 | -2 | 2 | 0 | 0 | 0 | 16:39 | 5 | 0.00 |
| Carter Hutton | G | Buf | 17 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 60:18 | 0 | 0.00 |
